Plenty of the best airlines in the Midwest region of the United States of America. The Midwest region is the most vibrant and preferred hub for air travel, connecting domestic and international destinations.
Midwest is the home of plenty of international airports, and major US-based international carriers offer convenient travel options for passengers traveling for business or leisure.
In this article, we will cover major airlines that flies to/from the Midwest region in the United States, and how passengers can make the most of it.

5 Best Airlines to Choose for Your Next Trip in the Midwest
After you understand the major airports that serve here, let’s delve into some of the best airlines in the Midwest:
1. Delta Air Lines
Being one of the most prominent airlines in the region, Delta Air Lines serves Minneapolis-St. Paul International Airport (MSP) as its primary hub.
The airline offers an extensive network of domestic and international flights, making it the preferred choice for passengers seeking premium service and hassle-free travel. The airline also offers direct flights to major airports in the United States, UK, and Europe.
2. American Airlines
American Airlines, a US-based carrier, operates more flights in the Midwest than any other airline covering over 250 airports domestically. Besides, the airline covers over 350 destinations worldwide making it one of the most reliable carriers in the Midwest region.
3. United Airlines
United Airlines uses Chicago O’Hare International Airport (ORD) as its primary hub for the Midwest region. The airline offers an extensive global network and has a partnership with Star Alliance members for seamless international connections.
4. Southwest Airlines
Being a low-cost and preferred airline for passengers in the US, Southwest Airlines serves as a primary hub for Kansas City International Airport (MCI) and Indianapolis International Airport (IND). The airline charges no hidden fee for checked bags, changes, or flight cancellations. Also, the best part is sales and promotional fares.
5. Allegiant Air
Allegiant Air caters to the tier 2 and tier 3 airports in the Midwest region. The airline serves as the primary hub for Cincinnati/Northern Kentucky International Airport (CVG) and Des Moines International Airport (DSM). The airline offers affordable fares and offers direct flights to key destinations like Florida and Las Vegas.
6. Frontier Airlines
Frontier Airlines is another low-cost carrier serving the Midwest region that offers budget-friendly flights under 49 USD from airports like Cleveland Hopkins International Airport (CLE) and St. Louis Lambert International Airport (STL).
Key Airports in the Midwest of the United States
After finding out the best airlines to go for in the Midwest region, let’s understand the major international airports in the Midwest region:
- Chicago O’Hare International Airport (ORD: This is one of the most prominent and most connected airports that serves as a major gateway in the Midwest region. It is the hub for United Airlines, Delta Airlines, and Southwest Airlines.
- Minneapolis-St. Paul International Airport (MSP): This is the hub for Delta Airlines, offering extensive connectivity for domestic and international flights.
- Detroit Metropolitan Wayne County Airport (DTW): Another hub for Delta Airlines which offers daily flights to over 100 cities around the US.
- Kansas City International Airport (MCI): This is the hub for Southwest Airlines which also offers flights to major international destinations like Aruba, Bahamas, and Puerto Vallarta.
- Indianapolis International Airport (IND): One of the major airports in the Southwest region that offers flights to major airports like Chicago (ORD or MDW), Detroit (DTW), Cincinnati (CVG), St. Louis (STL), Milwaukee (MKE), and Minneapolis-St. Paul (MSP).
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Summing Up…
To end with, the midwest region in the United States boasts an extensive aviation network operated by major carriers like American Airlines, Southwest Airlines, Delta Airlines, United Airlines, and other regional carriers like Envoy Air and Allegiant Air.
Whether you fly from one of the major airports like Minneapolis Airport or smaller cities like Des Moines, there are plenty of airlines to meet your needs.
Frequently Asked Questions (FAQs)
Major airlines include Delta Air Lines, American Airlines, and United Airlines which are the primary carriers that offer 100-plus flights daily from the Midwest region offering extensive domestic and international routes.
Southwest Airlines, Frontier Airlines, and Allegiant Airlines are certain budgeted carriers that serve in the Midwest region.
Some of the busiest airports include Chicago O’Hare (ORD), Minneapolis-St. Paul (MSP), and Detroit Metro (DTW).
Yes, regional carriers like Allegiant Airlines, Skywest, and Envoy Air offer connectivity to the smaller airports in the Midwest region.
Yes, low-cost carriers like Southwest Airlines, Frontier Airlines, and Allegiant Airlines offer direct flights that originate from the Midwest region to popular destinations like Las Vegas, Cancun, the Dominican Republic, Orlando, and New York.